MRPL16

Across TCGA patient cohorts, MRPL16 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL16-associated genes across cancer lineages are TIGAR, 14-3-3_zeta, and ATM. Each is linked with MRPL16 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL16-to-partner and partner-to-MRPL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by MRPL16-low versus MRPL16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL16→partner) and Y-score (partner→MRPL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.193	+3.026	.028	.019	3	1
UCEC	14-3-3_zeta →	+0.253	+3.026	.034	.019	3	1
UCEC	ATM →	-0.966	-3.000	<.001	.037	3	1
UCEC	DJ-1 →	+0.225	+3.000	.019	.037	3	1
UCEC	MSH6 →	-0.613	-3.000	.001	.037	2	1
UCEC	PCNA →	+0.377	+3.000	.002	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TIGAR by MRPL16 expression — UCEC

Explore this box plot interactively →