MRPL16

Across TCGA cell cohorts, MRPL16 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,019 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MRPL16-associated GO terms across cancer lineages are Pyruvate decarboxylation to acetyl-CoA, Mitochondrial translation, and Pseudouridine synthesis. Each is linked with MRPL16 in more than 12 cancer types. Because this analysis shows association rather than direction, both MRPL16-to-partner and partner-to-MRPL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pyruvate decarboxylation to acetyl-CoA grouped by MRPL16-low versus MRPL16-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL16→partner) and Y-score (partner→MRPL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Pyruvate decarboxylation to acetyl-CoA →	+0.139	+0.808	.002	<.001	3	13
BLOOD_Leukemia	Mitochondrial translation →	+0.082	+0.500	<.001	<.001	3	12
LARGE_INTESTINE	Pseudouridine synthesis →	+0.076	+0.830	<.001	<.001	3	11
OVARY	U1 snRNA 3'-end processing →	+0.087	+0.630	.002	<.001	3	11
OVARY	U5 snRNA 3'-end processing →	+0.087	+0.630	.002	<.001	3	11
SOFT_TISSUE	Amino acid activation →	+0.054	+0.492	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,019 associations by consensus.

Pyruvate decarboxylation to acetyl-CoA by MRPL16 expression — LIVER

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