MRPL15

Across TCGA pan-cancer cohorts, MRPL15 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPL15 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MRPL15 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPL15 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, LUAD, and LSCC are the cancer types where MRPL15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	1.000	0.897	.023	24	view →
LUAD	DFS	Quartile	II,III,IV	0.991	0.604	.005	13	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.739	.013	10	view →
CCRCC	DFS	Median	II,III,IV	0.575	0.830	.022	4	view →
GBM	OS	Tertile	All	0.465	0.306	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPL15–COAD (DFS)

Open the COAD breakdown →