MRPL15

Across TCGA patient cohorts, MRPL15 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL15-associated genes across cancer lineages are FOXO3a, MEK1, and p62 Lck ligand. Each is linked with MRPL15 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL15-to-partner and partner-to-MRPL15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by MRPL15-low versus MRPL15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL15→partner) and Y-score (partner→MRPL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	+0.132	+2.820	.009	.035	3	1
UCEC	MEK1 →	+0.456	+3.459	.012	.005	3	1
UCEC	p62 Lck ligand →	+0.465	+2.179	.004	.034	2	2
UCEC	Smad4 →	+0.122	+2.321	.045	.035	3	1
UCEC	Tuberin →	+0.324	+3.459	.016	.005	3	1
UCEC	4E-BP1_pT37_T46 →	-0.514	-2.321	.006	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FOXO3a by MRPL15 expression — UCEC

Explore this box plot interactively →