MRPL14

Across TCGA pan-cancer cohorts, MRPL14 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MRPL14 data layer compared with 29 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MRPL14 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPL14 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where MRPL14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.912	.013	72	view →
PDAC	DFS	Median	II,III,IV	0.465	0.314	.011	22	view →
HNSC	DFS	Quartile	III,IV	0.894	0.438	<.001	13	view →
CCRCC	OS	Median	All	0.833	0.973	.009	11	view →
LSCC	OS	Median	All	1.000	0.922	.011	7	view →
LUAD	DFS	Quartile	All	0.564	1.000	.043	3	view →
GBM	OS	Tertile	All	0.911	0.604	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MRPL14–COAD (DFS)

Open the COAD breakdown →