MRPL12

Across TCGA patient cohorts, MRPL12 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL12-associated genes across cancer lineages are RNU6-591P and SDR42E1P4. Each is linked with MRPL12 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL12-to-partner and partner-to-MRPL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-591P grouped by MRPL12-low versus MRPL12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL12→partner) and Y-score (partner→MRPL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-591P →	+0.652	+8.066	<.001	.007	3	1
UCEC	SDR42E1P4 →	+0.199	+8.066	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

RNU6-591P by MRPL12 expression — UCEC

Explore this box plot interactively →