MRPL12

Across TCGA cell cohorts, MRPL12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,314 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MRPL12-associated GO terms across cancer lineages are Response to endoplasmic reticulum stress, Succinate transmembrane transport, and Succinate transport. Each is linked with MRPL12 in more than 17 cancer types. Because this analysis shows association rather than direction, both MRPL12-to-partner and partner-to-MRPL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to endoplasmic reticulum stress grouped by MRPL12-low versus MRPL12-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL12→partner) and Y-score (partner→MRPL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Response to endoplasmic reticulum stress →	-0.077	-0.775	.001	<.001	3	18
BONE	Succinate transmembrane transport →	+0.296	+1.224	<.001	<.001	3	17
BONE	Succinate transport →	+0.296	+1.224	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Response to unfolded protein →	-0.071	-0.704	.005	.005	3	16
LUNG_SCLC	rRNA pseudouridine synthesis →	+0.145	+0.896	<.001	<.001	3	16
BLOOD_Myeloma	Ribosome assembly →	+0.083	+0.823	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,314 associations by consensus.

Response to endoplasmic reticulum stress by MRPL12 expression — BLOOD_Myeloma

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