MRPL11

Across TCGA pan-cancer cohorts, MRPL11 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MRPL11 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MRPL11 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPL11 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where MRPL11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	1.000	0.899	.029	18	view →
PDAC	OS	Tertile	All	0.551	0.262	.002	18	view →
HNSC	DFS	Median	IV	0.709	0.900	.032	5	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.860	.017	3	view →
CCRCC	DFS	Quartile	III,IV	0.637	0.915	.038	3	view →
LUAD	DFS	Median	All	0.545	0.866	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MRPL11–COAD (DFS)

Open the COAD breakdown →