MRPL1

Across TCGA patient cohorts, MRPL1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL1-associated genes across cancer lineages are eIF4E, MEK1, and p27_pT198. Each is linked with MRPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL1-to-partner and partner-to-MRPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MRPL1-low versus MRPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL1→partner) and Y-score (partner→MRPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.214	+2.321	.043	.035	3	1
UCEC	MEK1 →	+0.428	+2.999	.019	.035	3	1
UCEC	p27_pT198 →	+0.126	+2.321	.019	.035	3	1
UCEC	p62 Lck ligand →	+0.504	+2.321	.002	.035	3	1
UCEC	VHL →	-1.400	-3.169	<.001	.019	3	1
UCEC	ATM →	-0.607	-2.321	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

eIF4E by MRPL1 expression — UCEC

Explore this box plot interactively →