MROH9

Across TCGA patient cohorts, MROH9 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MROH9-associated genes across cancer lineages are 4E-BP1, C-Raf, and TAZ. Each is linked with MROH9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MROH9-to-partner and partner-to-MROH9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by MROH9-low versus MROH9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH9→partner) and Y-score (partner→MROH9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.256	+2.029	.001	.005	3	2
COAD	C-Raf →	+0.148	+3.204	.009	.008	3	2
SKCM	TAZ →	+0.137	+1.749	.030	.049	3	2
UCEC	eIF4E →	+0.191	+1.947	.003	<.001	3	2
UCEC	FoxM1 →	+0.158	+1.916	.046	.009	3	2
UCEC	GAPDH →	+0.359	+2.115	.028	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

4E-BP1 by MROH9 expression — UCEC

Explore this box plot interactively →