MROH8

Across TCGA patient cohorts, MROH8 mutation is significantly associated with the RNA expression of many other genes, with 1,888 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MROH8-associated genes across cancer lineages are IL31, SNORD105, and MIRLET7F1. Each is linked with MROH8 in more than 2 cancer types. Because this analysis shows association rather than direction, both MROH8-to-partner and partner-to-MROH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL31 grouped by MROH8-low versus MROH8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH8→partner) and Y-score (partner→MROH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IL31 →	+0.162	+1.729	.009	.001	3	3
CESC	SNORD105 →	+0.352	+3.359	.007	.003	3	3
READ	MIRLET7F1 →	+0.486	+4.533	.002	.004	3	3
BLCA	RPLP1P10 →	+0.180	+4.497	<.001	.009	3	3
SKCM	RPL21P66 →	+0.042	+1.928	<.001	.004	3	3
LIHC	RNU6-1020P →	+0.270	+5.008	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,888 associations by consensus.

IL31 by MROH8 expression — UCEC

Explore this box plot interactively →