MROH8

Across TCGA cell cohorts, MROH8 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MROH8-associated genes across cancer lineages are MAGEB4, ZAN, and OTOP1. Each is linked with MROH8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MROH8-to-partner and partner-to-MROH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by MROH8-low versus MROH8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH8→partner) and Y-score (partner→MROH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MAGEB4 →	+0.005	+3.700	<.001	.009	3	2
URINARY_TRACT	ZAN →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	OTOP1 →	+0.210	+5.087	<.001	.004	3	1
KIDNEY	CT47B1 →	+0.023	+5.000	<.001	.005	3	1
OESOPHAGUS	AKAIN1 →	+0.050	+4.017	.002	.007	3	1
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MAGEB4 by MROH8 expression — SKIN

Explore this box plot interactively →