Across TCGA patient cohorts, MROH7 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MROH7-associated genes across cancer lineages are mTOR_pS2448, MEK1, and Shc_pY317. Each is linked with MROH7 in more than 3 cancer types. Because this analysis shows association rather than direction, both MROH7-to-partner and partner-to-MROH7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH7→partner) and Y-score (partner→MROH7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.100	-1.342	.027	.034	3	4
UCEC	MEK1 →	+0.376	+2.392	<.001	<.001	3	3
UCEC	Shc_pY317 →	-0.133	-2.115	.004	.016	3	3
SKCM	TFRC →	+0.504	+1.847	.002	.006	3	3
COAD	Caspase-7-cleavedD198 →	+0.970	+3.330	.009	.005	3	3
UCEC	FoxM1 →	+0.194	+1.947	.014	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Exploration

MROH7 survival (RNA) · tumor vs normal (RNA) · all MROH7 data types