Across TCGA cell cohorts, MROH6 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MROH6-associated genes across cancer lineages are GZMK, ZNF705G, and DMRTC2. Each is linked with MROH6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MROH6-to-partner and partner-to-MROH6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH6→partner) and Y-score (partner→MROH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GZMK →	+0.063	+5.169	<.001	.005	3	1
BREAST	ZNF705G →	+0.006	+5.169	<.001	.005	3	1
SKIN	DMRTC2 →	+0.096	+5.415	<.001	.004	3	1
SKIN	PRSS58 →	+0.047	+4.977	<.001	.007	3	1
LARGE_INTESTINE	KLF18 →	+0.009	+3.930	<.001	.003	3	1
BLOOD_Leukemia	BTBD16 →	+0.124	+4.281	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

MROH6 survival (RNA) · tumor vs normal (RNA) · all MROH6 data types