Across TCGA patient cohorts, MROH5 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MROH5-associated genes across cancer lineages are GAPDH, p38-MAPK_pT180_Y182, and Cyclin-E2. Each is linked with MROH5 in more than 3 cancer types. Because this analysis shows association rather than direction, both MROH5-to-partner and partner-to-MROH5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH5→partner) and Y-score (partner→MROH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GAPDH →	+0.792	+3.169	.014	.020	3	4
UCEC	p38-MAPK_pT180_Y182 →	-0.306	-1.401	.028	.010	3	4
COAD	Cyclin-E2 →	+0.206	+3.321	.028	.009	3	3
BRCA	PCNA →	+0.285	+2.822	.004	.036	3	3
UCEC	PDK1_pS241 →	+0.145	+1.925	.006	.004	3	3
COAD	TIGAR →	+0.438	+2.008	.006	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Exploration

MROH5 survival (RNA) · tumor vs normal (RNA) · all MROH5 data types