MROH2B

Across TCGA patient cohorts, MROH2B mutation is significantly associated with the RNA expression of many other genes, with 5,804 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MROH2B-associated genes across cancer lineages are TYMS, RBBP8, and PAQR3. Each is linked with MROH2B in more than 4 cancer types. Because this analysis shows association rather than direction, both MROH2B-to-partner and partner-to-MROH2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMS grouped by MROH2B-low versus MROH2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH2B→partner) and Y-score (partner→MROH2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYMS →	+0.675	+1.491	<.001	<.001	3	5
UCEC	RBBP8 →	+0.708	+1.371	<.001	<.001	3	5
SKCM	PAQR3 →	+0.347	+0.923	<.001	<.001	3	5
HNSC	SEH1L →	+0.425	+2.233	.001	.005	2	5
SCLC	XYLB →	+0.645	+2.622	<.001	.003	3	4
UCEC	SLC25A33 →	+0.437	+2.083	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,804 associations by consensus.

TYMS by MROH2B expression — UCEC

Explore this box plot interactively →