MROH2B

Across TCGA patient cohorts, MROH2B mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MROH2B-associated genes across cancer lineages are c-Kit, PCNA, and Caspase-7-cleavedD198. Each is linked with MROH2B in more than 3 cancer types. Because this analysis shows association rather than direction, both MROH2B-to-partner and partner-to-MROH2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by MROH2B-low versus MROH2B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH2B→partner) and Y-score (partner→MROH2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	c-Kit →	-0.506	-1.874	.032	.049	3	4
UCEC	PCNA →	+0.186	+1.440	<.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+0.886	+3.459	.004	.005	3	4
UCEC	Cyclin-B1 →	+0.587	+1.584	<.001	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.127	-1.700	.002	.001	3	3
LUSC	MSH6 →	+0.290	+1.257	.021	.027	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

c-Kit by MROH2B expression — COAD

Explore this box plot interactively →