MROH2B

Across TCGA cell cohorts, MROH2B mutation is significantly associated with the RNA expression of many other genes, with 384 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MROH2B-associated genes across cancer lineages are FAM71E2, SPINK13, and OR2L5. Each is linked with MROH2B in more than 2 cancer types. Because this analysis shows association rather than direction, both MROH2B-to-partner and partner-to-MROH2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71E2 grouped by MROH2B-low versus MROH2B-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH2B→partner) and Y-score (partner→MROH2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FAM71E2 →	+0.046	+2.938	.002	.008	3	3
BLOOD_Leukemia	SPINK13 →	+0.237	+3.718	<.001	<.001	3	3
OESOPHAGUS	OR2L5 →	+0.010	+3.273	.001	.004	3	2
OESOPHAGUS	INSRR →	+0.108	+2.938	.007	.008	3	2
CNS	VSTM1 →	+0.716	+3.040	<.001	.002	3	2
LUNG_SCLC	PHLDA1 →	+1.713	+3.106	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 384 associations by consensus.

FAM71E2 by MROH2B expression — OESOPHAGUS

Explore this box plot interactively →