MRNIP

Across TCGA pan-cancer cohorts, MRNIP mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MRNIP data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MRNIP mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MRNIP expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where MRNIP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.914	0.778	.005	14	view →
CCRCC	DFS	Median	All	0.704	1.000	.008	8	view →
LSCC	DFS	Median	All	0.905	1.000	.048	1	view →
LUAD	OS	Tertile	All	0.892	0.756	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MRNIP–PDAC (OS)

Open the PDAC breakdown →