MRNIP

Across TCGA pan-cancer cohorts, MRNIP mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MRNIP’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where MRNIP mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MRNIP is over-expressed in tumor, although a few such as PDAC and LSCC show the opposite, repressed pattern.

PDAC, CCRCC, and LSCC are the cancer types where MRNIP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRNIP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−0.567	<.001	8	view →
CCRCC	Male	II,III,IV	+0.377	<.001	8	view →
LSCC	Female	All	−0.365	<.001	8	view →
LUAD	All	II,III,IV	−0.136	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MRNIP–PDAC

Open the PDAC breakdown →