MRNIP

Across TCGA patient cohorts, MRNIP mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRNIP-associated genes across cancer lineages are MEK1, Notch1, and PCNA. Each is linked with MRNIP in more than 1 cancer types. Because this analysis shows association rather than direction, both MRNIP-to-partner and partner-to-MRNIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MRNIP-low versus MRNIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRNIP→partner) and Y-score (partner→MRNIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.513	+3.169	.010	.020	3	1
UCEC	Notch1 →	+0.243	+3.013	.001	.018	3	1
UCEC	PCNA →	+0.243	+3.000	.040	.036	3	1
UCEC	Annexin-1 →	+0.871	+3.019	.002	.019	3	1
UCEC	ATM →	-0.644	-3.169	.009	.020	3	1
UCEC	4E-BP1_pT37_T46 →	-0.641	-3.169	.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MEK1 by MRNIP expression — UCEC

Explore this box plot interactively →