MRM3

Across TCGA pan-cancer cohorts, MRM3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MRM3 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MRM3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRM3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

LSCC, CCRCC, and COAD are the cancer types where MRM3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.912	0.619	.001	17	view →
CCRCC	DFS	Tertile	II,III,IV	0.440	0.859	.007	14	view →
COAD	DFS	Median	III,IV	1.000	0.899	.046	12	view →
LUAD	DFS	Quartile	II,III,IV	0.991	0.658	.021	7	view →
GBM	OS	Quartile	All	0.659	0.415	.022	4	view →
HNSC	OS	Median	All	1.000	0.958	.020	4	view →
PDAC	DFS	Tertile	IV	0.741	0.203	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MRM3–LSCC (DFS)

Open the LSCC breakdown →