MRM3

Across TCGA patient cohorts, MRM3 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRM3-associated genes across cancer lineages are Macrophages, Macrophages M1, and Macrophages M2. Each is linked with MRM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRM3-to-partner and partner-to-MRM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macrophages grouped by MRM3-low versus MRM3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRM3→partner) and Y-score (partner→MRM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Macrophages →	+0.029	+3.288	.009	.041	3	2
UCEC	Macrophages M1 →	+0.020	+2.279	.003	.047	3	1
UCEC	Macrophages M2 →	+0.010	+3.024	.038	.019	2	2
UCEC	Plasma cells →	-0.021	-2.887	.038	.037	2	1
UCEC	Class-switched memory B-cells →	-0.065	-3.700	.015	.001	1	1
UCEC	lymphatic Endothelial cells →	-0.028	-3.646	.012	.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Macrophages by MRM3 expression — COAD

Explore this box plot interactively →