MRM2

Across TCGA patient cohorts, MRM2 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRM2-associated genes across cancer lineages are Neutrophils, Epithelial cells, and Th2 cells. Each is linked with MRM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRM2-to-partner and partner-to-MRM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neutrophils grouped by MRM2-low versus MRM2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRM2→partner) and Y-score (partner→MRM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Neutrophils →	+0.030	+3.469	<.001	.031	3	3
UCEC	Epithelial cells →	-0.133	-3.000	.001	.037	3	1
UCEC	Th2 cells →	+0.316	+3.008	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Neutrophils by MRM2 expression — LUSC

Explore this box plot interactively →