MRM2

Across TCGA cell cohorts, MRM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,847 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MRM2-associated GO terms across cancer lineages are Meiotic mismatch repair, rRNA 2'-O-methylation, and Positive regulation of isotype switching to IgG isotypes. Each is linked with MRM2 in more than 16 cancer types. Because this analysis shows association rather than direction, both MRM2-to-partner and partner-to-MRM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic mismatch repair grouped by MRM2-low versus MRM2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRM2→partner) and Y-score (partner→MRM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Meiotic mismatch repair →	+0.105	+1.031	<.001	<.001	3	17
BONE	rRNA 2'-O-methylation →	+0.135	+0.580	<.001	<.001	3	16
OVARY	Positive regulation of isotype switching to IgG isotypes →	+0.138	+0.858	<.001	<.001	3	15
SOFT_TISSUE	Positive regulation of spindle checkpoint →	+0.140	+0.710	<.001	<.001	3	13
SOFT_TISSUE	Positive regulation of mitotic cell cycle spindle assembly checkpoint →	+0.140	+0.710	<.001	<.001	3	13
SOFT_TISSUE	Positive regulation of cell cycle checkpoint →	+0.131	+0.664	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,847 associations by consensus.

Meiotic mismatch repair by MRM2 expression — BLOOD_Myeloma

Explore this box plot interactively →