MRM1

Across TCGA patient cohorts, MRM1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRM1-associated genes across cancer lineages are ATM, mTOR, and eEF2. Each is linked with MRM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRM1-to-partner and partner-to-MRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MRM1-low versus MRM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRM1→partner) and Y-score (partner→MRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.993	-2.986	<.001	.035	3	2
UCEC	mTOR →	-0.238	-3.000	.010	.037	3	1
UCEC	eEF2 →	+0.458	+3.000	.026	.037	2	1
UCEC	Notch1 →	+0.219	+2.817	.007	.036	2	1
UCEC	PCNA →	+0.290	+3.000	.020	.037	2	1
UCEC	PEA-15_pS116 →	+0.434	+3.000	.032	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ATM by MRM1 expression — UCEC

Explore this box plot interactively →