MRI1

Across TCGA pan-cancer cohorts, MRI1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MRI1 data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher MRI1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MRI1 expression acts as an unfavorable survival marker.

MESO, SKCM, and ESCA are the cancer types where MRI1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.077	0.580	<.001	42	view →
SKCM	DFS	Median	All	0.290	0.762	<.001	16	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MRI1–MESO (OS)

Open the MESO breakdown →