MRI1

Across TCGA patient cohorts, MRI1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRI1-associated genes across cancer lineages are p62 Lck ligand, PKC-a, and STAT5a. Each is linked with MRI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRI1-to-partner and partner-to-MRI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by MRI1-low versus MRI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRI1→partner) and Y-score (partner→MRI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.578	+3.584	<.001	.002	3	1
UCEC	PKC-a →	+0.478	+3.013	.014	.018	3	1
UCEC	STAT5a →	+0.495	+3.000	.010	.036	3	1
UCEC	VHL →	-1.382	-3.584	<.001	.002	3	1
UCEC	CD49b →	-0.401	-3.156	.003	.018	3	1
UCEC	INPP4B →	-0.318	-3.169	.041	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p62 Lck ligand by MRI1 expression — UCEC

Explore this box plot interactively →