MRI1

Across TCGA cell cohorts, MRI1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRI1-associated genes across cancer lineages are VSIG4, PRSS54, and MS4A2. Each is linked with MRI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRI1-to-partner and partner-to-MRI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VSIG4 grouped by MRI1-low versus MRI1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRI1→partner) and Y-score (partner→MRI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	VSIG4 →	+0.030	+5.285	<.001	.003	3	1
BLOOD_Lymphoma	PRSS54 →	+0.046	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	MS4A2 →	+0.013	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	C11orf97 →	+2.118	+5.209	<.001	.005	3	1
BLOOD_Leukemia	GHRHR →	+0.322	+3.705	<.001	.007	3	1
BLOOD_Leukemia	SELENOV →	+0.081	+4.339	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

VSIG4 by MRI1 expression — STOMACH

Explore this box plot interactively →