MRGPRX3

Across TCGA patient cohorts, MRGPRX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,972 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MRGPRX3-associated GO terms across cancer lineages are Positive regulation of nervous system development, Chondroitin sulfate metabolic process, and Transcription by RNA polymerase I. Each is linked with MRGPRX3 in more than 11 cancer types. Because this analysis shows association rather than direction, both MRGPRX3-to-partner and partner-to-MRGPRX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of nervous system development grouped by MRGPRX3-low versus MRGPRX3-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRX3→partner) and Y-score (partner→MRGPRX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of nervous system development →	+0.061	+0.156	<.001	<.001	3	12
STAD	Chondroitin sulfate metabolic process →	+0.066	+0.141	<.001	<.001	3	12
STAD	Transcription by RNA polymerase I →	+0.108	+0.162	<.001	<.001	3	11
STAD	Ribonucleoside monophosphate biosynthetic process →	+0.055	+0.095	<.001	<.001	3	11
STAD	rRNA metabolic process →	+0.067	+0.090	<.001	.001	3	11
SCLC	Obsolete histone methylation →	+0.125	+0.530	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,972 associations by consensus.

Positive regulation of nervous system development by MRGPRX3 expression — STAD

Explore this box plot interactively →