MRGPRX3

Across TCGA patient cohorts, MRGPRX3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MRGPRX3-associated genes across cancer lineages are MEK1, PCNA, and c-Myc. Each is linked with MRGPRX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRGPRX3-to-partner and partner-to-MRGPRX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MRGPRX3-low versus MRGPRX3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRX3→partner) and Y-score (partner→MRGPRX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MEK1 →	+0.248	+3.025	.016	.019	3	3
UCEC	PCNA →	+0.248	+1.906	.004	.016	3	2
COAD	c-Myc →	-0.338	-2.991	.005	.036	3	1
UCEC	Notch1 →	+0.166	+2.415	.003	.003	3	1
UCEC	14-3-3_epsilon →	+0.095	+1.906	.017	.016	3	1
UCEC	STAT3_pY705 →	-0.326	-1.906	.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MEK1 by MRGPRX3 expression — COAD

Explore this box plot interactively →