MRGPRX3

Across TCGA cell cohorts, MRGPRX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 489 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MRGPRX3-associated GO terms across cancer lineages are Membrane repolarization, Protein targeting to ER, and Establishment of protein localization to endoplasmic reticulum. Each is linked with MRGPRX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRGPRX3-to-partner and partner-to-MRGPRX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane repolarization grouped by MRGPRX3-low versus MRGPRX3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRX3→partner) and Y-score (partner→MRGPRX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Membrane repolarization →	+0.122	+0.677	.006	.009	3	3
LUNG_NSCLC_LUSC	Protein targeting to ER →	+0.081	+0.048	.003	.008	3	3
LUNG_NSCLC_LUSC	Establishment of protein localization to endoplasmic reticulum →	+0.062	+0.044	.006	.001	3	3
SKIN	Positive regulation of myeloid leukocyte differentiation →	+0.093	+1.291	<.001	<.001	3	3
SKIN	Positive regulation of catecholamine secretion →	+0.183	+1.862	.005	.007	3	3
LIVER	Regulation of CD40 signaling pathway →	+0.178	+0.045	.001	.002	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 489 associations by consensus.

Membrane repolarization by MRGPRX3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →