MRGPRX3

Across TCGA cell cohorts, MRGPRX3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MRGPRX3-associated genes across cancer lineages are COL6A5, OR4F21, and SSX3. Each is linked with MRGPRX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRGPRX3-to-partner and partner-to-MRGPRX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL6A5 grouped by MRGPRX3-low versus MRGPRX3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRX3→partner) and Y-score (partner→MRGPRX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COL6A5 →	+0.420	+3.724	<.001	.004	3	1
LARGE_INTESTINE	OR4F21 →	+0.139	+2.878	<.001	.009	3	1
LUNG_SCLC	SSX3 →	+1.909	+3.237	<.001	.008	3	1
LUNG_SCLC	CASP12 →	+0.114	+3.099	<.001	.003	3	1
LUNG_SCLC	HBM →	+0.339	+2.906	.005	.007	3	1
UPPER_AERODIGESTIVE_TRACT	OPN1MW →	+0.036	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

COL6A5 by MRGPRX3 expression — LARGE_INTESTINE

Explore this box plot interactively →