MRGPRX2

Across TCGA patient cohorts, MRGPRX2 mutation is significantly associated with the RNA expression of many other genes, with 3,896 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRGPRX2-associated genes across cancer lineages are GLRXP2, RN7SL568P, and SNORD116-25. Each is linked with MRGPRX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRGPRX2-to-partner and partner-to-MRGPRX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLRXP2 grouped by MRGPRX2-low versus MRGPRX2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRX2→partner) and Y-score (partner→MRGPRX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GLRXP2 →	+0.044	+2.606	.003	.005	3	2
HNSC	RN7SL568P →	+0.272	+3.428	<.001	.006	3	2
HNSC	SNORD116-25 →	+0.304	+4.608	<.001	.005	3	2
UCEC	MIER2 →	+0.468	+3.708	<.001	<.001	3	2
UCEC	KXD1 →	+0.547	+4.032	<.001	<.001	3	2
UCEC	UBE2S →	+0.679	+2.939	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,896 associations by consensus.

GLRXP2 by MRGPRX2 expression — SKCM

Explore this box plot interactively →