MRGPRX2

Across TCGA cell cohorts, MRGPRX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 315 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible MRGPRX2-associated GO terms across cancer lineages are Regulation of protein localization to mitochondrion, Regulation of kinase activity, and Blood coagulation, fibrin clot formation. Each is linked with MRGPRX2 in more than 4 cancer types. Because this analysis shows association rather than direction, both MRGPRX2-to-partner and partner-to-MRGPRX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to mitochondrion grouped by MRGPRX2-low versus MRGPRX2-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRX2→partner) and Y-score (partner→MRGPRX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of protein localization to mitochondrion →	+0.064	+0.040	<.001	.005	3	5
LARGE_INTESTINE	Regulation of kinase activity →	+0.030	+0.006	.001	.009	3	4
LARGE_INTESTINE	Blood coagulation, fibrin clot formation →	+0.226	+0.007	.001	.004	3	4
STOMACH	Negative regulation of protein catabolic process →	+0.090	+0.010	<.001	.005	3	4
LUNG_NSCLC_LUAD	Hemidesmosome assembly →	+0.172	+0.014	<.001	.003	3	4
BLOOD_Leukemia	Negative regulation of epithelial cell apoptotic process →	+0.066	+0.052	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 315 associations by consensus.

Regulation of protein localization to mitochondrion by MRGPRX2 expression — BLOOD_Leukemia

Explore this box plot interactively →