MRGPRX1

Across TCGA patient cohorts, MRGPRX1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRGPRX1-associated genes across cancer lineages are C-Raf, cIAP, and JNK2. Each is linked with MRGPRX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRGPRX1-to-partner and partner-to-MRGPRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by MRGPRX1-low versus MRGPRX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRX1→partner) and Y-score (partner→MRGPRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.182	+2.459	.008	.020	3	2
SKCM	cIAP →	+0.106	+1.703	.030	.011	3	2
UCEC	JNK2 →	+0.218	+3.009	.023	.019	3	1
UCEC	MEK1 →	+0.454	+3.169	.010	.018	3	1
UCEC	Notch1 →	+0.182	+2.459	.007	.020	3	1
UCEC	PKC-b-II_pS660 →	-0.288	-2.459	.031	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

C-Raf by MRGPRX1 expression — UCEC

Explore this box plot interactively →