MRGPRX1

Across TCGA cell cohorts, MRGPRX1 RNA expression is significantly associated with the mutation status of many other genes, with 65 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRGPRX1-associated genes across cancer lineages are DMBT1, NECTIN1, and SETD1B. Each is linked with MRGPRX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRGPRX1-to-partner and partner-to-MRGPRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMBT1 grouped by MRGPRX1-low versus MRGPRX1-high in URINARY_TRACT.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRX1→partner) and Y-score (partner→MRGPRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DMBT1 →	+4.087	+0.157	.009	.001	3	2
OVARY	NECTIN1 →	+4.700	+0.022	.002	.007	3	2
OESOPHAGUS	SETD1B →	+3.392	+0.138	.007	<.001	3	1
OESOPHAGUS	DNAH14 →	+4.392	+0.146	.003	<.001	3	1
SOFT_TISSUE	ANKRD50 →	+4.635	+2.249	.003	<.001	3	1
PANCREAS	ABCC11 →	+4.786	+0.114	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

DMBT1 by MRGPRX1 expression — URINARY_TRACT

Explore this box plot interactively →