MRGPRX1

Across TCGA cell cohorts, MRGPRX1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRGPRX1-associated genes across cancer lineages are SLC2A7, G6PC2, and RBP2. Each is linked with MRGPRX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRGPRX1-to-partner and partner-to-MRGPRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC2A7 grouped by MRGPRX1-low versus MRGPRX1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRX1→partner) and Y-score (partner→MRGPRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC2A7 →	+0.016	+4.906	<.001	.006	3	2
SKIN	G6PC2 →	+0.033	+3.141	.007	.002	3	1
BLOOD_Leukemia	RBP2 →	+0.040	+4.037	.002	.004	3	1
BLOOD_Leukemia	NPFFR1 →	+0.013	+4.037	<.001	.004	3	1
BLOOD_Leukemia	KLK15 →	+0.501	+3.769	<.001	.008	3	1
BLOOD_Leukemia	UCN3 →	+0.018	+3.855	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

SLC2A7 by MRGPRX1 expression — OESOPHAGUS

Explore this box plot interactively →