Across TCGA patient cohorts, MRGPRE mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible MRGPRE-associated genes across cancer lineages are RN7SL266P, MIR569, and SOD1P2. Each is linked with MRGPRE in more than 1 cancer types. Because this analysis shows association rather than direction, both MRGPRE-to-partner and partner-to-MRGPRE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRE→partner) and Y-score (partner→MRGPRE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RN7SL266P →	+0.359	+5.352	<.001	.005	3	2
BLCA	MIR569 →	+0.596	+5.251	<.001	.006	3	2
COAD	SOD1P2 →	+0.497	+5.145	<.001	.007	3	2
SKCM	RPL30P1 →	+0.199	+4.034	<.001	.004	3	2
UCEC	RNA5SP421 →	+1.166	+4.603	<.001	.001	3	2
BLCA	CYCTP →	+0.222	+5.038	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

Exploration

MRGPRE survival (RNA) · tumor vs normal (RNA) · all MRGPRE data types