Across TCGA cell cohorts, MRGPRE RNA expression is significantly associated with the go_rna of many other GO terms, with 341 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRGPRE-associated GO terms across cancer lineages are Regulation of tumor necrosis factor-mediated signaling pathway, Regulation of mitochondrion organization, and Regulation of cytokine-mediated signaling pathway. Each is linked with MRGPRE in more than 4 cancer types. Because this analysis shows association rather than direction, both MRGPRE-to-partner and partner-to-MRGPRE results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRE→partner) and Y-score (partner→MRGPRE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.038	+0.056	.009	.003	3	4
LARGE_INTESTINE	Regulation of mitochondrion organization →	+0.039	+0.042	.007	.004	2	5
LARGE_INTESTINE	Regulation of cytokine-mediated signaling pathway →	+0.044	+0.067	<.001	.001	3	4
CNS	Negative regulation of ATP metabolic process →	+0.083	+0.021	<.001	.006	3	3
PANCREAS	Negative regulation of stress fiber assembly →	+0.111	+0.046	<.001	.009	3	3
LUNG_SCLC	Regulation of neuron projection arborization →	+0.086	+0.690	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 341 associations by consensus.

Exploration

MRGPRE survival (RNA) · tumor vs normal (RNA) · all MRGPRE data types