Across TCGA cell cohorts, MRGPRE mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRGPRE-associated genes across cancer lineages are IFNA2, MEIKIN, and MSGN1. Each is linked with MRGPRE in more than 1 cancer types. Because this analysis shows association rather than direction, both MRGPRE-to-partner and partner-to-MRGPRE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRE→partner) and Y-score (partner→MRGPRE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IFNA2 →	+0.019	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	MEIKIN →	+0.085	+4.887	.002	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.134	+4.930	<.001	.001	3	1
LARGE_INTESTINE	LINC02881 →	+0.013	+4.415	.005	.007	3	1
LARGE_INTESTINE	SPO11 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	FAM181B →	+0.182	+4.139	.006	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

MRGPRE survival (RNA) · tumor vs normal (RNA) · all MRGPRE data types