MREG

Across TCGA patient cohorts, MREG mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MREG-associated genes across cancer lineages are EGFR, ERK2, and FASN. Each is linked with MREG in more than 1 cancer types. Because this analysis shows association rather than direction, both MREG-to-partner and partner-to-MREG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by MREG-low versus MREG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MREG→partner) and Y-score (partner→MREG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.221	-2.222	.001	.011	3	1
UCEC	ERK2 →	+0.217	+2.999	.008	.035	3	1
UCEC	FASN →	+0.411	+2.222	.014	.011	3	1
UCEC	FOXO3a_pS318_S321 →	-0.154	-2.575	.003	.010	3	1
UCEC	HER2_pY1248 →	-0.231	-2.906	.041	.001	3	1
UCEC	INPP4B →	-0.354	-2.209	.009	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

EGFR by MREG expression — UCEC

Explore this box plot interactively →