MREG

Across TCGA cell cohorts, MREG RNA expression is significantly associated with the go_rna of many other GO terms, with 5,600 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MREG-associated GO terms across cancer lineages are Aorta smooth muscle tissue morphogenesis, Negative regulation of bone mineralization involved in bone maturation, and Keratinocyte development. Each is linked with MREG in more than 13 cancer types. Because this analysis shows association rather than direction, both MREG-to-partner and partner-to-MREG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aorta smooth muscle tissue morphogenesis grouped by MREG-low versus MREG-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MREG→partner) and Y-score (partner→MREG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Aorta smooth muscle tissue morphogenesis →	-1.162	-1.126	<.001	<.001	3	14
PANCREAS	Negative regulation of bone mineralization involved in bone maturation →	-1.463	-0.876	<.001	.002	3	11
URINARY_TRACT	Keratinocyte development →	-0.484	-1.710	<.001	<.001	3	11
SKIN	Minus-end-directed organelle transport along microtubule →	+0.164	+1.332	<.001	<.001	3	11
OVARY	Metanephric glomerulus morphogenesis →	-0.669	-0.787	.009	<.001	3	11
OVARY	Metanephric glomerulus vasculature morphogenesis →	-0.669	-0.787	.009	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,600 associations by consensus.

Aorta smooth muscle tissue morphogenesis by MREG expression — URINARY_TRACT

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