MRE11

Across TCGA pan-cancer cohorts, MRE11 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRE11 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MRE11 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MRE11 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

UCEC, LUAD, and PDAC are the cancer types where MRE11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.433	1.000	.007	32	view →
LUAD	DFS	Quartile	II,III,IV	0.706	0.259	.015	10	view →
PDAC	DFS	Median	All	0.801	0.722	.019	7	view →
COAD	DFS	Tertile	All	1.000	0.924	.049	6	view →
HNSC	OS	Quartile	III,IV	0.769	0.969	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRE11–UCEC (OS)

Open the UCEC breakdown →