MRC2

Across TCGA patient cohorts, MRC2 protein abundance is significantly associated with the RNA expression of many other genes, with 22,258 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MRC2-associated genes across cancer lineages are COL1A1, COL5A1, and POSTN. Each is linked with MRC2 in more than 9 cancer types. Because this analysis shows association rather than direction, both MRC2-to-partner and partner-to-MRC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MRC2 versus COL1A1 in GBM, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRC2→partner) and Y-score (partner→MRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL1A1 →	+2.620	+0.600	<.001	<.001	3	10
GBM	COL5A1 →	+1.928	+0.717	<.001	<.001	3	10
GBM	POSTN →	+3.014	+0.533	<.001	<.001	3	10
GBM	COL6A2 →	+1.801	+0.606	<.001	<.001	3	10
BRCA	ADAM12 →	+1.779	+0.820	<.001	<.001	3	10
GBM	COL6A3 →	+2.139	+0.667	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,258 associations by consensus.

MRC2 vs COL1A1 — GBM

Explore this scatter interactively →