MRC2

Across TCGA patient cohorts, MRC2 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRC2-associated genes across cancer lineages are CD49b, Caspase-7-cleavedD198, and eIF4E. Each is linked with MRC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MRC2-to-partner and partner-to-MRC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD49b grouped by MRC2-low versus MRC2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRC2→partner) and Y-score (partner→MRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CD49b →	+0.190	+1.339	.033	.044	3	4
COAD	Caspase-7-cleavedD198 →	+1.604	+3.008	<.001	.019	3	4
SKCM	eIF4E →	+0.138	+2.087	.041	.005	3	3
COAD	Lck →	+0.486	+3.025	.002	.019	3	3
COAD	PCNA →	+0.259	+3.008	.044	.019	2	4
UCEC	eEF2 →	+0.268	+2.700	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

CD49b by MRC2 expression — SKCM

Explore this box plot interactively →