MRC2

Across TCGA cell cohorts, MRC2 mutation is significantly associated with the RNA expression of many other genes, with 867 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRC2-associated genes across cancer lineages are GZMK, EML5, and TADA2B. Each is linked with MRC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRC2-to-partner and partner-to-MRC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by MRC2-low versus MRC2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRC2→partner) and Y-score (partner→MRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GZMK →	+0.005	+4.614	<.001	.004	3	3
LARGE_INTESTINE	EML5 →	+0.799	+2.949	.001	<.001	3	3
LARGE_INTESTINE	TADA2B →	+0.573	+2.265	.001	.001	3	3
URINARY_TRACT	CD300E →	+0.032	+5.044	<.001	<.001	3	2
BREAST	ZNF479 →	+0.046	+4.199	.001	.007	3	2
BLOOD_Leukemia	INSM2 →	+0.132	+3.354	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 867 associations by consensus.

GZMK by MRC2 expression — PANCREAS

Explore this box plot interactively →