MRC2

Across TCGA cell cohorts, MRC2 mutation is significantly associated with the mutation status of many other genes, with 5,530 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRC2-associated genes across cancer lineages are EPG5, BIRC6, and INSRR. Each is linked with MRC2 in more than 6 cancer types. Because this analysis shows association rather than direction, both MRC2-to-partner and partner-to-MRC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPG5 grouped by MRC2-low versus MRC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRC2→partner) and Y-score (partner→MRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPG5 →	+3.347	+3.472	<.001	<.001	1	7
CNS	BIRC6 →	+2.470	+4.222	.003	.003	1	6
CNS	INSRR →	+3.055	+3.786	.006	.006	1	6
CNS	MYO9A →	+2.818	+4.536	.001	.001	1	6
UPPER_AERODIGESTIVE_TRACT	TRIP11 →	+5.193	+4.539	<.001	<.001	1	6
STOMACH	THSD7A →	+3.584	+3.584	.006	.006	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,530 associations by consensus.

EPG5 by MRC2 expression — BLOOD_Leukemia

Explore this box plot interactively →