MRC1

Across TCGA pan-cancer cohorts, MRC1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MRC1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MRC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRC1 expression acts as an unfavorable survival marker.

COAD, UCEC, and CCRCC are the cancer types where MRC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.880	1.000	.012	66	view →
UCEC	DFS	Tertile	All	0.710	0.942	.009	20	view →
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	18	view →
LUAD	DFS	Median	III,IV	0.586	0.898	.007	16	view →
HNSC	DFS	Median	II,III,IV	0.899	0.991	.005	9	view →
GBM	OS	Tertile	All	0.747	0.963	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MRC1–COAD (DFS)

Open the COAD breakdown →