MRC1

Across TCGA patient cohorts, MRC1 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRC1-associated genes across cancer lineages are Cyclin-B1, ACC1, and FoxM1. Each is linked with MRC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MRC1-to-partner and partner-to-MRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by MRC1-low versus MRC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRC1→partner) and Y-score (partner→MRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.630	+1.502	<.001	<.001	3	4
COAD	ACC1 →	+0.481	+3.169	.006	.017	3	4
UCEC	FoxM1 →	+0.184	+1.469	.007	.006	3	3
UCEC	JNK_pT183_Y185 →	-0.120	-1.584	.007	.008	3	3
COAD	ASNS →	+0.792	+3.467	<.001	.002	3	3
COAD	4E-BP1 →	+0.237	+2.330	.016	.020	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

Cyclin-B1 by MRC1 expression — UCEC

Explore this box plot interactively →